• Bhawana Sethi Department of Pharmaceutics, Innovative College of Pharmacy, Plot No. 6, Knowledge Park-II, Greater Noida, Uttar Pradesh 201306, India
  • Rupa Mazumder Department of Pharmaceutics, Noida Institute of Engineering & Technology, Greater Noida, Uttar Pradesh 201306, India



Transdermal patch, Penetration enhancer, Permeability coefficient, Flux


Objective: Aliskiren hemifumarate is used for the treatment of hypertension. The aim of this research to study the effect on the delivery of drug using natural and synthetic permeation enhancers like limonene, cineol, β-cyclodextrin, and oleic acid by using different polymers. As different penetration acts differently with polymers.

Methods: Transdermal patches were prepared by the solvent evaporation technique. The controlled release polymers were used for the preparation of patches. The patches were prepared with different polymers and different plasticizer. The drug and polymer interaction study was performed by Fourier transform infrared spectra. In vitro permeation studies were conducted using pretreated cellophane membrane using franz diffusion cell.

Results: The prepared patches were evaluated for in vitro drug release, and the release profile was varied from 52.32% PGH (oleic acid) to 87.63% B (cineol). The permeability coefficient was found in the range of 5.82 to 8.32 cm/h, and corresponding flux was found between 281.61 to 729.08 µg/cm2/h on the prepared patches and statistical analysis performed using t-test (p<0.005).

Conclusion: On the basis of the obtained results, it was concluded that patch prepared using methocel k 15 m as a polymer, glycerin as plasticizer and cineol as a permeation enhancer shows the maximum release. The increase in the release due to increase in the flux.


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Hamid RM, Adrian CW, Brian WB. A lamellar matrix model for stratum corneum intercellular lipids. Effects of terpene penetration enhancers on the structure and thermal behavior of the matrix. Int J Pharm 1997;146:41-54.

Fuhrman Jr LC, Michniak BB, Behl CR, Malick AW. Effect of novel penetration enhancers on the transdermal delivery of hydrocortisone: an in vitro species comparison. J Controlled Release 1997;45:199-206.

Jia You F, Li Ren H, Yaw Bin H, Yi Hung T. Evaluation of transdermal iontophoresis of enoxacin from polymer formulations: in vitro skin permeation and in vivo microdialysis using wistar rat as an animal model. Int J Pharm 1999;180:137–49.

Victor MM, Clive SR. Inter-and intra-individual variability in human skin barrier function: a large scale retrospective study. Toxi In Vitro 2008;22:1062–9.

Yakov F, Gillian ME, Victor MM. Factors influencing hydrocortisone permeation into human hair follicles: use of the skin sandwich system. Int J Pharm 2008;358:144–50.

Taravat G, Parinaz Z, Hamed H, Ali N. The effect of penetration enhancers on drug delivery through the skin: a QSAR study. J Controlled Release 2004;99:113–25.

Jitendra B, Subhash P, Pathak AK. Development and optimization of the transdermal system of lisinopril dehydrate: employing permeation enhancers. Iran J Pharm Sci Aut 2010;6:245-51.

Indu V, Abdul A, Mohd A, Suraj PA. Investigating the potential of essential oils as a penetration enhancer for transdermal losartan delivery: effectiveness and mechanism of action. Asian J Pharm Sci 2014;9:260-7.

Vineet M, Yamini S, Mithun SR. Physical and chemical penetration enhancers in transdermal drug delivery system. Asian J Pharm 2010;7:173-83.

R Jayachandra B, Muralikrishnan D, Siva RV, Singh PN, Pandit JK. Cardiovascular effects of transdermally delivered bupranolol in rabbits: Effect of chemical penetration enhancers. Life Sci 2008;82:273–8.

Andega S, Kanikkannan N, Singh M. Comparison of the effect of fatty alcohols on the permeation of melatonin between porcine and human skin. J Controlled Release 2001;77:17–25.

Jin K, Sang Chul S. Controlled release of atenolol from the ethylene-vinyl acetate matrix. Int J Pharm 2004;273:23–7.

Udhumansha U, Molugu VSR, Kumaresan R, Roop KK, Farhan JA. The transdermal therapeutic system of carvedilol: effect of hydrophilic and hydrophobic matrix on in vitro and in vivo characteristics. AAPS PharmSciTech 2007;8:E1-8.

Chomchan A, ItsueI, Ken-ichi O, Kazutaka H, Toshikiro K. Skin permeation of propranolol from a polymeric film containing terpene enhancers for transdermal use. Int J Pharm 2005;289:167–78.

Reeta RG, Swantrant KJ, Manoj V. AOT water-in-oil microemulsions as a penetration enhancer in transdermal drug delivery of 5-fluorouracil. Colloids Surf B 2005;41:25–32.

Zainab AS, Nawal AR. Studying the effect of different variables on the formulation of mucoadhesive buccal patches of captopril. Int J Appl Pharm 2017;9:16-21.

Asha D, Abdul BA. Formulation and evaluation of transdermal patch of indomethacin containing patchouli oil as natural penetration enhancer. Asian J Pharm Clin Res 2017;10:320-5.

Khushpal K, Preetinder K, Sunny J, Upendra KJ. Formulation and in vitro evaluation of transdermal matrix patches of doxofylline. Asian J Pharm Clin Res 2016;9:140-5.

Andre LMR, Eduardo CF, Aline GP, Ana CZL, Magali BA, Gislaine RP, et al. In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil. Brazil J Pharm Sci 2013;49.

Sadeghi AMM, Dorkoosh FA, Avadi MR, Weinhold M, Bayat A. Permeation enhancer effect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in caco-2 cells. Eur J Pharm Biopharm 2008;70:270–8.



How to Cite

Sethi, B., & Mazumder, R. (2019). COMPARISON OF EFFECT OF PENETRATION ENHANCER ON DIFFERENT POLYMERS FOR DRUG DELIVERY. International Journal of Applied Pharmaceutics, 11(1), 89–93.



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